Thiomaltol

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August undefined, 2024

WebMar 7, 2024 · Biological evaluation of novel thiomaltol-based organometallic complexes as topoisomerase IIα inhibitors Authors (first, second and last of 6) Maria S. Legina; Juan J. Nogueira; Bernhard K. Keppler; Content type: Original Paper Open Access; Published: 19 March 2024; Pages: 451 - 465 ... WebNov 17, 2003 · Complexes of thiomaltol with nickel(II) and iron(III) have been prepared and studied by using UV-visible spectroscopy and electrochemical methods. In addition, both complexes as well as the free thiomaltol ligand have been structurally characterized by using single-crystal X-ray diffraction methods.

Kinetic characterization of a slow-binding inhibitor of …

Webthiomaltol, the enzyme at a final assay concentration of 0.13 µg/mL was incubated with 159 µM and 1.59mM thiomaltol, which corresponds to the IC 50 value at 60min preincubation … WebOct 19, 2016 · Thiomaltol, a potential S,O-coordinating molecule, has been utilized for the complexation of four different organometallic fragments, yielding the desired Ru II, Os II, … che bar doncaster

Supplementary Information - Royal Society of Chemistry

WebSep 21, 2004 · The lead(II) ion is regarded as a serious environmental contaminant. A considerable need exists to develop selective ligands for remediation of this metal ion. Herein, the coordination chemistry of lead(II) is investigated with three O,S donor ligands: thiomaltol, 3-hydroxy-1-methyl-2(1H)-pyridinethione (3,2-HOPTO), and 3-hydroxy-1,2 … Web2.2 Synthesis and Characterization of Thiomaltol (26) and 3,4-HOPTO derivatives 21, 27-44 (26) Thiomaltol Thiomaltol was synthesized according to a literature procedure outlined by Flematti et al.8 Maltol (1.26 g, 10.0 mmol, 1.0 equiv.) was dissolved in THF (30 mL) and a solution of P2S5 (3.34 g, 15.0 mmol, 1.5 equiv.) dissolved WebThe O,S-donor analogues of maltol and deferiprone (DMHP), respectively, thiomaltol and DMHTP, have been investigated in solution for their iron-complexation ability, as well as their electrochemical behaviors, in the presence and absence of iron, aimed at the rationalization of their anti-oxidant activity, particularly, as hydroxyl radical scavengers and inhibitors of … che bar blackpool

Thiomaltol‐Based Organometallic Complexes with …

WebNov 1, 2010 · The thiomaltol compounds show promising in vitro activity with IC50 values (50% inhibitory concentration) in the low micromolar range, whereas activity of the maltol complexes is marginal. WebOct 9, 2024 · Thiomaltol, a potential S,O-coordinating molecule, has been utilized for the complexation of four different organometallic fragments, yielding the desired Ru II, Os II, Rh III, and Ir III complexes having a “piano-stool” configuration. In addition to the synthesis of these compounds with a chlorido leaving group, the analogous 1-methylimidazole … che bap vietnamese sweet corn puddingWebSep 6, 2013 · This unprecedented binding mode in the hCAII-thiomaltol complex has been characterized by both X-ray crystallography and X-ray spectroscopy. In addition, the steric restrictions of the active site force the ligands into a 'flattened' mode of coordination compared with inorganic model complexes. This change in geometry has been shown by … che bar aruba

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Thiomaltol

WebThus, at the physiological pH there is a higher percent formation of MoO 3 L for the thio-compounds: ca 90% for thiomaltol and 60% for DMHTP; ca 52% for maltol and 5% for DMHP. Analysis of the pMo values in Table 1 shows that the softer O, S-donor ligands (thiomaltol and DMHTP) have a slightly higher affinity for the Mo(VI) than the harder O, O ... WebSep 1, 2012 · In fact, as thiomaltol is a weaker iron chelator than maltol, the presence of thiomaltol results in a higher concentration of free iron than in the presence of the oxo-compound. Therefore, more radicals should exist and less lipid peroxidation inhibition occurs for low concentrations of thiomaltol. Nevertheless, thiomaltol has also a higher ...

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WebMaltol definition, a crystalline compound, C6H6O3, obtained from larch bark, pine needles, chicory, or roasted malt, used for enhancing flavors and aromas, as in foods, wines, and … WebDownload Table Crystal data and summary of data collection and refinement of [MoO 2 (thiomaltol)] 2 (l-O), complex 1, and [MoO 2 (thiomaltol) 2 ], complex 2 from publication: Biologically ...

WebMar 19, 2024 · Recently published findings [] on the anticancer properties of novel Ru II, Os II, Rh III, and Ir III thiomaltol complexes showed that they act as inhibitors of topo2 catalytic … WebExpanding the reactive sulfur species metabolome : characterization of small oxoacids of sulfur and hydrogen sulfide within in vitro and in vivo models and use of the ionophore thiomaltol to target melanoma in a copper-dependent mechanism.

WebSep 27, 2024 · The thiomaltol ligand (L2) is known to be highly cytotoxic by itself. 46 While the activities in SW480 and CH1/PA-1 cell lines of complex 2 are within the same range as that of the free ligand (L2), the activity of 2 in the A549 cell line is significantly greater (4 to 5 times) when compared with the free ligand L2. WebOct 19, 2016 · Thiomaltol, a potential S,O‐coordinating molecule, has been utilized for the complexation of four different organometallic fragments, yielding the desired Ru II, Os II, …

WebThiomaltol: CAS Number: 23060-85-7: Synonyms: 2-Methyl-3-hydroxy-4-thiopyrone; 3-Hydroxy-2-methyl-4-pyranthione; 3-Hydroxy-2-methyl-4H-pyran-4-thione: Molecular Weight: …

WebJan 11, 2013 · Thiomaltol and Bla2 preparation. The enzyme Bla2 was purified as previously described 10.The purity of the product after Ni 2+ chromatography was determined by … cheba powder stay in your hair how lingWebOct 19, 2016 · Abstract Thiomaltol, a potential S,O‐coordinating molecule, has been utilized for the complexation of four different organometallic fragments, yielding the desired RuII, … che bar chicagoWebthiomaltol. More... Molecular Weight: 142.18. Dates: Modify . 2024-01-28. Create . 2005-09-13. Contents. 1 Structures Expand this section. 2 Names and Identifiers Expand this section. 3 Chemical and Physical Properties Expand this section. 4 Related Records Expand this section. 5 Chemical Vendors. che bar high streetWebDec 27, 2024 · In this report we investigate the toxicity of the ionophore thiomaltol (Htma) and Cu salts to melanoma. Divalent metal complexes of thiomaltol display toxicity against A375 melanoma cell culture resulting in a distinct apoptotic response at sub-micromolar concentrations, with toxicity of Cu(tma)2 > Zn(tma)2 >> Ni(tma)2. che barnettWebIn the case of thiomaltol, formation of tris complexes is also likely at high pH. The replacement of the chlorido by the aqua ligand in the [Ru(II)(η(6)-p-cymene)(L)(Cl)] species was monitored, which is an important activation step in the course of the mode of action of the complexes, facilitating binding to biological targets. che bar northeimWebDivalent metal complexes of thiomaltol display toxicity against A375 melanoma cell culture resulting in a distinct apoptotic response at sub-micromolar concentrations, with toxicity of Cu(tma)2 ... chebar pronounce chebar in the bible