WebType 1 interferon (T1IFN), a ubiquitous and pleiotropic family of cytokines, is a critical mediator of the response to viral, bacterial, and other antigens sampled in the intestine. Although inflammation is enhanced in mouse model of colitis when T1IFN signaling is lost, the action of T1IFN is context specific and can be pro- or anti-inflammatory. WebJul 16, 2024 · Canonical T1IFN-induced gene expression ( MX1, PKR, and IFIT1) ( 24 ), was measured using qPCR. The relative expression of these three genes was standardized to healthy donors and summed to generate a score reflecting the ability of sera to cause T1IFN-induced gene expression (serum T1IFN activity).
Type 1 Interferon in the Human Intestine—A Co-ordinator of the …
WebCytokine autoantibodies, particularly those directed to type I interferon (T1IFN), have been reported to portend an increased risk of severe COVID-19. Since SLE is one of the conditions historically associated with T1IFN autoantibodies, we sought to determine the prevalence of cytokine autoantibodies in our local cohort of 173 patients with SLE prepandemic and … WebStudying the temporal dynamics of anti-T1IFN autoantibodies, we found that autoantibody levels remained stable in patients with AIRE deficiency and thymic malignancies, but were highly dynamic in patients with acute … recent studies of ancient maya water
B-Cell-Intrinsic Type 1 Interferon Signaling Is Crucial for …
WebT1IFN signaling in contrast, only modestly contributed to autoimmune responses and the disease process in these mice. TLR7 ligand imiquimod treated IFN-g reporter mice show that CD4 + effector T cells including follicular helper T (Tfh) cells are the major producers of TLR7-induced IFN-g. WebAug 12, 2024 · Type I interferon (IFN-I; IFNα and IFNβ) functions in both autocrine and paracrine manners to induce the expression of various interferon-stimulated genes (ISGs) … WebJul 1, 2024 · The most remarkable result for all oncogenes and models tested was the downregulation of type 1 interferon (T1IFN) and antiviral response proteins, especially those associated with viral dsRNA sensing. recent studies on mental health