WebApr 23, 2024 · Sanofi brain-penetrant BTK inhibitor significantly reduced disease activity in Phase 2 trial in relapsing multiple sclerosis Primary and secondary objectives were met with 85% or greater relative reduction achieved in the number of new gadolinium-enhancing T1 and new or enlarging T2 hyperintense lesions No new safety signals identified WebAug 31, 2024 · Inhibitor Phase is a book that gives the space opera a good name. It shuns some of the complexities of the genre by concentrating on one character. What it does not skimp on is the intelligent ideas and action that are also staples of the genre. For a book that cover vast areas of space it is surprisingly welcoming and easy to read.
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WebApr 12, 2024 · ROCKVILLE, Md. and SHANGHAI, April 12, 2024 /PRNewswire/ -- SciNeuro Pharmaceuticals today announced that SNP318, a novel Lp-PLA2 inhibitor, is advancing into Phase 1 clinical trials in Australia, positioning it for global development.SNP318 is a small molecule, optimized for CNS penetrance, to induce broader anti-inflammatory benefits. It … WebJan 3, 2024 · NEW YORK--(BUSINESS WIRE)--Pfizer Inc. (NYSE: PFE) announced today the initiation of a Phase 2b/3 clinical trial for its oral JAK3 inhibitor, PF-06651600, for the treatment of patients with moderate to severe alopecia areata, a chronic autoimmune skin disease that causes hair loss on the scalp, face, or body, and currently has no approved …
WebAug 13, 2024 · In a phase Ib/II clinical trial (NORSE study), the safety and antitumor activity of erdafitinib in combination with cetrelimab (an IgG4 anti–programmed cell death protein 1 [PD-1] inhibitor) was evaluated in patients with metastatic urothelial harboring susceptible FGFR2/3 alternations . Patients were enrolled after progression on one or more ... WebApr 14, 2024 · AbstractPurpose:. Inhibition of monocarboxylate transporter (MCT) 1–mediated lactate transport may have cytostatic and/or cytotoxic effects on tumor cells. We report results from the dose-escalation part of a first-in-human trial of AZD3965, a first-in-class MCT1 inhibitor, in advanced cancer.Patients and Methods:. This multicentre, …
WebOct 4, 2024 · Inhibitor Phase (Audible Audio) Published October 13th 2024 by Orbit. Unabridged Audiobook, Audible Audio, 19 pages. more details. Want to Read. Rate this book. 1 of 5 stars 2 of 5 stars 3 of 5 stars 4 of 5 stars 5 of 5 stars. WebAim: We evaluated MK-8353 (small molecule inhibitor of extracellular signal-regulated kinase 1/2) plus selumetinib (mitogen-activated extracellular signal-regulated kinase 1/2 inhibitor) in patients with advanced solid tumors. Methods: This phase 1b, open-label, dose-escalation study ...
WebMay 25, 2024 · Phase Ib trial to evaluate safety and anti-tumor activity of the AKT inhibitor, ipatasertib, in combination with endocrine therapy and a CDK4/6 inhibitor for patients with …
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