WebMay 19, 2024 · The NLRP3 inflammasome is a multi-molecular complex that acts as a molecular platform to mediate caspase-1 activation, leading to IL-1β/IL-18 maturation and … WebMay 17, 2013 · In order to efficiently characterize both antiproliferative potency and mechanism of action of small molecules targeting the cell cycle, we developed a high …
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WebAug 22, 2013 · Hepatocellular carcinoma (HCC) is a major public health problem due to increased incidence, late diagnosis and limited treatment options. TGF-β is known to … WebSustained oncogenic AKT signaling was common, while non-essential, in treatment-mediated cytostatic cancer cells harboring PI3K-pathway mutations, which are … butchery signs
USP9X mediates an acute adaptive response to MAPK …
WebImportantly, we observed a specific downregulation of target genes of the canonical Wnt signaling pathway, which was accompanied by decreased nuclear localization of active β-catenin. Together our data uncover a previously unknown role for SSRP1 in promoting the activation of the Wnt signaling pathway activity during cellular differentiation. WebSignaling by the many ligands of the TGFβ family strongly converges towards only five receptor-activated, ... Therefore, we have investigated the individual roles of Smad2 and … Webreceptor binding (first messenger), a signal transduction pathway is initiated. Factors affecting homeostasis in the skin and ... Necrosis of some tumors in vivo, cytostatic for certain cell lines in vitro, many overlap-ping functions with IL-1; several overlapping effects with IL-6 and IL-1 ccw with psychological medication