Cyp17a1蛋白
WebCytochrome P450 17A1 (CYP17A1; also P450c17and P450sccII) is a critically important enzyme in humans that catalyzes the formation of all endogenous androgens. It is an atypical cytochrome P450 enzyme in that it catalyzes two distinct types of substrate oxidation. Through its hydroxylase activity, it … WebFunction. A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis ( PubMed: 9452426, PubMed: 27339894, PubMed: 22266943, PubMed: 25301938 ). Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an …
Cyp17a1蛋白
Did you know?
Web1.雄激素受体信号传导途径的抑制剂和p38抑制剂的药物组合，其用于治疗个体中的前列腺癌，其中前列腺肿瘤细胞表达ar-v7变体雄激素受体蛋白，或用于预防在通过雄激素受体信号传导途径的抑制剂治疗的患有前列腺癌的患者中抵抗性的发生。 2.根据权利要求1所述的用于治疗前列腺癌的药物组合 ... Web把经过封闭的蛋白膜与稀释好的一抗4℃缓慢摇动过夜或室温缓慢摇动2小时，确保稀释的抗体至少能在摇动的瞬间覆盖蛋白膜。 ... CYP17A1 Rabbit Polyclonal Antibody. AF8067. 50μl. StAR Rabbit Polyclonal Antibody. AF6228. 50μl. ARF6 Rabbit Polyclonal Antibody. AF6234. 50μl. ASC/TMS1 Rabbit Polyclonal ...
CYP17A1 is a 57.4 kDa protein that belongs to the cytochrome P450 family. The protein encoded by its cDNA is composed of 508 amino acid residues. As an enzyme, CYP17A1 possesses an active site that associates with a heme prosthetic group to catalyze biosynthetic reactions. See more Cytochrome P450 17A1 (steroid 17α-monooxygenase, 17α-hydroxylase, 17-alpha-hydroxylase, 17,20-lyase, 17,20-desmolase) is an enzyme of the hydroxylase type that in humans is encoded by the … See more Gene The CYP17A1 gene resides on chromosome 10 at the band 10q24.3 and contains 8 exons. The cDNA of this gene spans a length of 1527 bp. This gene encodes a member of the cytochrome P450 superfamily … See more CYP17A1 is a member of the cytochrome P450 superfamily of enzymes localized in the endoplasmic reticulum. Proteins in this family are monooxygenases that catalyze synthesis of cholesterol, steroids and other lipids and are involved in drug metabolism. CYP17A1 has both … See more • Pregnenolone • 17α-Hydroxypregnenolone • Progesterone • 17α-Hydroxyprogesterone See more Expression of CYP17A1 has been found in all of the traditional steroidogenic tissues except the placenta, including the zona reticularis and zona fasciculata of the adrenal cortex, the Leydig cells of the testes, the thecal cells of the ovaries, and, more recently, in See more Mutations in this gene are associated with rare forms of congenital adrenal hyperplasia, specifically 17α-hydroxylase deficiency/17,20-lyase deficiency and isolated 17,20-lyase deficiency See more CYP17A1 inhibitors Currently, the FDA has approved only one CYP17A1 inhibitor, abiraterone, which contains a steroidal … See more Web重组蛋白： 多项发明专利，真核、原核表达系统稳定表达3000余种蛋白，生物活性良好； 产品定制： ELISA试剂盒、抗体、重组蛋白根据您需求可提供专业定制服务。
Webcyp17a1蛋白屬於細胞色素p450氧化酶超家族的一員，定位於內質網，既有甾體的17α-羥化酶也有17,20-解離酶活性，在類固醇生成途徑中將孕烯醇酮或孕酮的d環上17號c原子上α … WebCYP21A2蛋白；细胞色素P450家族成员21B (CYP21A2)重组蛋白两个建议：. 1、用非变性纯化样品去做EK酶切、纯化。. 如果融合蛋白的降解是从N端开始的，而C端没有降解，那么应该能够拿到38肽。. 我曾经有个这么个类似情况，酶切后证实是N端降解，C端的目的蛋白好 …
WebThe CYP17A1 gene provides instructions for making a member of the cytochrome P450 enzyme family. Like other cytochrome P450 enzymes, CYP17A1 is involved in the formation (synthesis) of steroid hormones. This group of hormones includes sex hormones such as testosterone and estrogen, which are needed for normal sexual development and …
trader joe\u0027s cashew milkWeb进一步实验证实CPSF6是通过APA调节作用于下游靶点基因人宫颈癌癌基因2(HCCR2)，使其具有缩短3'UTR的转录本高表达，翻译更多的蛋白，进而调节肝癌的增殖和转移过程。另外，实验中发现let-7a、let-7c、miR-26a三种miRNA结合在CPSF6基因3'UTR上直接抑制基因的 … trader joe\u0027s cashew butter cashewsWeb肾上腺皮质腺瘤CYP17A1及3BHSD2蛋白的免疫组化研究. 目的:应用免疫组织化学染色方法观察17α羟化酶 (CYP17A1),3β羟基类固醇脱氢酶2 (3BHSD2)在人正常肾上腺及其肿瘤组织中的分布特点,探讨CYP17A1,3BHSD2免疫组化检测对病理诊断肾上腺醛固酮分泌腺瘤 (APA),皮质醇分泌腺瘤 ... trader joe\u0027s cat cookieshttp://www.delta-f.com/highchemical/protac%20linker?page=7550 trader joe\u0027s cat cookies for peopleWeb1 day ago · 春季常吃哪些食物护肝？. 以下是春季养肝护肝的一些食物：. 1.苦味食物：苦瓜、黄芩、枸杞子等具有清热解毒的作用，适量食用可以促进胆汁分泌，帮助肝脏排毒。. … trader joe\u0027s cashew quesoWeb抗cyp17a1抗体(d-12)在各种科学出版物中有12篇引文。 针对哺乳动物靶标蛋白的一抗，如抗cyp17a1 抗体 (d-12)，推荐用于检测一系列哺乳动物物种，主要有小鼠，大鼠和人物种。 许多哺乳动物抗体也非常适合兽医研究，与羊、猪、羊、猫、犬、牛和马的蛋白靶点反应。 the russian cosmists细胞色素 P450 17A1（英語：Cytochrome P450 17A1）也被称为甾体17α-单加氧酶（steroid 17α-monooxygenase），17α-羟基化酶（17α-hydroxylase），17,20-碳链裂解酶（17,20-lyase 或 17,20-desmolase）是一种羟基化酶，由位于人类10号染色体的 CYP17A1 基因编码 。这一基因在许多组织与细胞中都有表达，特别是肾上腺皮质的网状带（英语：zona reticularis）和 … trader joe\u0027s cashew yogurt ingredients