Cisplatin apoptosis induction
WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different … WebAt the end of the execution phase, the apoptotic signal must come back to the nucleus to produce internucleosomal DNA degradation. Therefore, the induction of apoptosis from …
Cisplatin apoptosis induction
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WebThere is the possibility of slow ligand-exchange for cisplatin dissolved in water. Our usual advice is to prepare and use solutions on the same day. In this case we strongly suggest … WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in …
WebWe have shown previously that β-elemene increases cisplatin cytotoxicity and enhances cisplatin sensitivity via blocking cell cycle progression at G2/M phase in resistant ovarian tumor cells. In the current study, we asked whether β-elemene-augmented cisplatin activity in ovarian carcinoma cells is mediated through the induction of apoptosis. WebCisplatin resistance is a daunting obstacle in cancer therapy and one of the major causes for treatment failure due to the inadequate drug activity and apoptosis induction. To overcome cisplatin resistance, we proposed a multifunctional nanogel (designated as Valproate-D-Nanogel) capable of reactivating cisplatin and enhancing early apoptosis.
WebApr 7, 2016 · Tubular cell apoptosis plays an essential pathogenic role for cisplatin-induced AKI. In this study, cell apoptosis was examined by terminal deoxynucleotidyl transferase-mediated digoxigenin-deoxyuridine nick-end labeling (TUNEL) staining and immuno-staining for cleaved caspase 3 in kidney tissues.
WebIn this study, cisplatin was found to induce apoptosis in a cochlear cell line, in a dose- and duration-dependent manner. Specific caspase assays revealed an early (6 h) but transient increase in caspase 8 activity, and a delayed (12 h) increase in caspase 9 activity. The enhanced caspase 8 activity was preceded by upregulation of p53 ...
WebCisplatin (cis-diamminedichloroplatinum; CDDP) 1 is a potent inducer of growth arrest and/or apoptosis in most cell types and is among the most effective and widely used chemotherapeutic agents employed for treatment of human cancers. However, a major limitation of CDDP chemotherapy is serious drug resistance. greenbackin phone numberWebAdditionally, to determine the effects of the combination of TAS and cisplatin on the apoptosis of NSCLC cells, flow cytometry was used to detect the apoptosis rate in A549 cells treated with cisplatin alone or combination therapy. ... Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA … green back hummingbirdWebCisplatin-induced testicular damage is a major obstacle in the application of cisplatin as chemotherapeutic agent. However, it remains as one of the most widel 掌桥科研 一站式科研服务平台 flowers fernandina beach flWebJan 16, 2024 · One of the most common treatments for this type of cancer is chemotherapy by cisplatin, which induces apoptosis in cancer cells. Apoptosis is a type of physiological cell death. Cisplatin chemotherapy usually has several side effects and cellular resistance to cisplatin is a common incidence. flowers fernandina beach floridaWebCisplatin (cis-diamminedichloroplatinum (II), DDP) is an antineoplastic agent widely used in the treatment of solid tumors because of its extensive cytotoxic activity. However, the main limiting side effect of DDP use is nephrotoxicity, a rapid deterioration in kidney function due to toxic chemicals. Several studies have shown that epigenetic processes are involved in … flowers fernley nvWebOct 23, 2003 · Induction of p73-dependent apoptosis by cisplatin has two requirements: (1) drug-activated c-Abl tyrosine kinase and (2) cellular proficiency of the MMR complex, which, as with HMG1, links... flowers ferndale miWebCisplatin helps in the treatment of various types of cancers in the body like such as ovarian, lung, head and neck, testicular and bladder. 5 Cisplatin is efficient in use against various types of cancers such as germ cell tumors, sarcomas, carcinomas as well as lymphomas. greenback ir free